Returning to Florence to find it occupied by the Duke of Urbino, Leonardo joins forces with Carlo to free Clarice and liberate the city, but Carlo reveals himself to be an agent of the Labyrinth and kills Verrocchio.
Meanwhile, Lucrezia is interrogated by the Sultan's soothsayer, who after learning the truth of Lucrezia's parentage explains that her father wants to start a war between Christendom and the Ottoman Empire. Riario, now wanting to follow the true Pope, asks for absolution, but the real Sixtus angrily rejects him. Later, in Naples, Ferrante is assassinated, thus putting Lorenzo at the Pope's mercy.
